Heyward has three brothers. His youngest brother Connor played as a tight end for Michigan State. On April 30, 2022, the Pittsburgh Steelers drafted Connor as a tight end in the sixth round of the 2022 NFL draft.
Heyward was born in Pittsburgh, Pennsylvania. His late father Craig “Ironhead” Heyward was a former NFL fullback. His father died from cancer, and Cameron was fined by the NFL for uniform violations when he displayed his father’s nickname in an eye black message during the NFL’s 2015 Breast Cancer Awareness campaign.
Cameron stated that being part of the NFL was a blessing and he wanted to honor his dad and raise cancer awareness. During Heyward’s freshman year at Ohio State University, he began dating Allie Schwarzwalder and proposed to her on New Year’s Eve 2012 at Savoy. On May 11, 2013, they were married at Westin Convention Center at the Pittsburgh Hotel in Pittsburgh, Pennsylvania.